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Sunday 7 September 2014

BIOCHEMISTRY PAPER 1-1ST MBBS KUHS-2014 AUGUST





Q.P.Code:105001                                             Reg.no:…………….
First professional MBBS Degree Examinations, August 2014
BIOCHEMISTRY-PAPER I
Time: 3Hours                                           Total Marks:50
Answer all questions
Draw diagrams wherever necessary

Essay (10)
1. Describe the pathway for synthesis of urea. Add a note on the regulation of the pathway. Name two conditions in which blood urea is increased giving the biochemical basis or enzyme defect *
(5+3+2=10)
OR
Define β-oxidation. Explain reactions of β-oxidation of palmitic acid. Add a note on energetics.**

Short essays (2×5=10)

2. Kreb’s cycle*/ TCA cycle**
3. Important compounds derived from glycine

Short notes (5×3=15)

4. Enumerate three types of enzyme specificity
5. Lactose intolerance
6. Transamination
7. Significance of the HMP shunt
8. Uncouplers of oxidative phosphorylation

Answer briefly (5×2=10)

9. Active methionine
10. Biological action of glutathione
11. Hartnup’s disease
12. Clinical significance of ALP
13. Alkaptonurea

Give precise answers (5×1=5)

14. Name the deficient enzyme in Niemann Pick disease
15. Mention the normal level of serum creatinine
16. What is iso-electric pH
17. Mention any two key enzymes of glycolysis
18. Name four lipotropic factors

*Question changed
**New question